Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase
Identifieur interne : 000057 ( 1957/Analysis ); précédent : 000056; suivant : 000058Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase
Auteurs : Tadanobu Takahashi [États-Unis, Japon] ; Chairul A. Nidom [Indonésie] ; Mai Thi Quynh Le [Viêt Nam] ; Takashi Suzuki [Japon] ; Yoshihiro Kawaoka [États-Unis, Japon]Source :
- FEBS Open Bio [ 2211-5463 ] ; 2012.
Abstract
Avian influenza A viruses (IAVs) and human 1918, 1957, and 1968 pandemic IAVs all have neuraminidases (NAs) that are stable at low pH sialidase activity, yet most human epidemic IAVs do not. We examined the pH stability of H5N1 highly pathogenic avian IAV (HPAI) NAs and identified amino acids responsible for conferring stability at low pH. We found that, unlike other avian viruses, most H5N1 IAVs isolated since 2003 had NAs that were unstable at low pH, similar to human epidemic IAVs. These H5N1 viruses are thus already human virus-like and, therefore, have the frequent infections of humans.
Url:
DOI: 10.1016/j.fob.2012.08.007
PubMed: 23650608
PubMed Central: 3642167
Affiliations:
- Indonésie, Japon, Viêt Nam, États-Unis
- Région de Kantō, Wisconsin
- Madison (Wisconsin), Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
Links toward previous steps (curation, corpus...)
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- to stream 1957, to step Extraction: 000057
Links to Exploration step
PMC:3642167Le document en format XML
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We examined the pH stability of H5N1 highly pathogenic avian IAV (HPAI) NAs and identified amino acids responsible for conferring stability at low pH. We found that, unlike other avian viruses, most H5N1 IAVs isolated since 2003 had NAs that were unstable at low pH, similar to human epidemic IAVs. These H5N1 viruses are thus already human virus-like and, therefore, have the frequent infections of humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Basler, C F" uniqKey="Basler C">C.F. Basler</name></author><author><name sortKey="Aguilar, P V" uniqKey="Aguilar P">P.V. Aguilar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uchida, Y" uniqKey="Uchida Y">Y. Uchida</name></author><author><name sortKey="Chaichoune, K" uniqKey="Chaichoune K">K. Chaichoune</name></author><author><name sortKey="Wiriyarat, W" uniqKey="Wiriyarat W">W. 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Suzuki</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Indonésie</li><li>Japon</li><li>Viêt Nam</li><li>États-Unis</li></country><region><li>Région de Kantō</li><li>Wisconsin</li></region><settlement><li>Madison (Wisconsin)</li><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li><li>Université du Wisconsin à Madison</li></orgName></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Takahashi, Tadanobu" sort="Takahashi, Tadanobu" uniqKey="Takahashi T" first="Tadanobu" last="Takahashi">Tadanobu Takahashi</name></region><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></country><country name="Japon"><noRegion><name sortKey="Takahashi, Tadanobu" sort="Takahashi, Tadanobu" uniqKey="Takahashi T" first="Tadanobu" last="Takahashi">Tadanobu Takahashi</name></noRegion><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name></country><country name="Indonésie"><noRegion><name sortKey="Nidom, Chairul A" sort="Nidom, Chairul A" uniqKey="Nidom C" first="Chairul A." last="Nidom">Chairul A. Nidom</name></noRegion></country><country name="Viêt Nam"><noRegion><name sortKey="Quynh Le, Mai Thi" sort="Quynh Le, Mai Thi" uniqKey="Quynh Le M" first="Mai Thi" last="Quynh Le">Mai Thi Quynh Le</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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